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Natural Science Forum / Biology / Biology / April 2006Realistic Biology & Software Initiative??
Greetings, Soliciting opinions regarding the promise (and hype) around in-silico modeling of COMPLETE cellular activity. I sincerely believe that a revolution in healthcare can occur if signficant government resources are used to create simulations of all organelles and cellular components of human cells. Is this a realistic "moon-shot" or just an idealistic rant? Maybe a set of projects each with "Human Genome Project" type funding will be needed to create this over a 9-12 year period. Is this worth it or should we just continue on incremental progress in wet-lab and data mining type of projects? I've blogged [http://nanothought.blogspot.com/2006/03/biological-simulations-next-great-era_16.html] a congratulations to the University of Illinois computational biology about their Viral simulation and would like to solicit opinions from real micro-biologists that work day-to-day on the complexities of cellular functions. Any thoughts? Bert -------------------------------------------- Breaking Health News - http://www.healthcubes.com/portal I think that yes, it is worth doing, but that we are 10-30 years away from the processing power needed to do it. A good modeling of a single receptor-ligand interaction can take weeks on a decent supercomputer, the resources nessicary to model an entire cell are just too astranomical at the current moment. Maybe different level of abstractions (and granularity) should be modeled (and layered) to help reduce the computational needs ... for instance instead of going down to the level of exact positional and physical attributes of each protein (which demands huge cpu/memory resources)... we can abstract up one level and just consider eletrical charge, behavior and other aspects of biochemistry that can still provide significant insight and research avenues .... and once all the models of the individual cellular components start coming together in an integrated model - unforseen relationships and behavior can start emerging. Bert ------------------------------------------- Breaking Health News - http://www.healthcubes.com/portal This is done already to no success already:) http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TCX-49M6R24-2&_coverD ate=11%2F30%2F2003&_alid=380257199&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=5182&_s ort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=5ab0dff057 4575e8824307cbaab3752c Exactly what you are looking for, but sorry it's not a freetext, you may have to go to your library. More details about this project I found at http://www.nrcam.uchc.edu/ And it seems that it is sponsored exactly by NIH. Also quick search by Google gives: http://ecell.sourceforge.net/ can you send me info on palestine_pimp90@hotmail.com |
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