Natural Science Forum / Biology / Biology / June 2006

There has never been direct observable evidence of prion molecule
replication. I have been discussing the Prusiner Model for 10 years now
and find it very much flawed and in error.

There are many diseases of a similar category. They are Alzheimers,
Parkinsons, Prion and others. In the past few years it was found that
well-water bacteria can cause Parkinsons. All of these are brain
wasting diseases.

All of them are very much similar. And that would indicate that the
cause of Alzheimers, Parkinsons and Prion are similar. So if bacteria
are the cause of Parkinsons, then, believe you me, Prion is caused by
some virus or bacteria and not this hoky poky out of this world new
mechanism of Prusiner.

Just today I ran across this below message about birdflu virus and what
immediately struck me was the protein missile. So that a viral protein
missile could damage the synthesis in the body of the prion-molecule
manufacture site. Prion disease would not be where Protein A changes
the form of Protein B. Rather instead, the disease is that some viral
missile altered the manufacturing site of where prion molecules are
formed and like a cookie cutter deformed and puts out deformed cookies.

--- quoting NIH ---
Source: NIH/National Institute Of Allergy And Infectious Diseases

Posted: December 4, 2001

Scientists Find Hidden Piece Of Influenza Virus

For nearly 20 years, scientists have labored under the assumption that
the influenza virus comprises only 10 protein molecules that form its
structure and carry out its activities. However, this week in Nature
Medicine researchers report finding a new, "hidden" influenza virus
protein. This protein may kill immune system cells that fight the
virus, thereby contributing to the virus's potency, the researchers
say.

"We believe this is a groundbreaking finding, although we're not yet
sure how deep the ground is," says Jonathan Yewdell, M.D., Ph.D., a
viral immunologist who led a team of scientists at the National
Institute of Allergy and Infectious Diseases (NIAID). "This might be
the 'grand canyon' of the flu, in terms of understanding this virus's
virulence, or perhaps only a narrow side ravine."

The scientists turned up this new protein by accident, while sifting
through bits and pieces of "junk" peptides. Junk peptides are short
protein molecules the virus creates once it infects a cell and begins
replicating. They form when the process that translates viral genes
into proteins goes awry, Dr. Yewdell explains. In other words, junk
peptides result from genetic mistakes.

"We weren't looking for new proteins at all. We assumed the 10 known
influenza proteins were all there were," Dr. Yewdell says. "We just
wanted to know if immune system cells had learned to recognize any of
these junk peptides. We thought that was an interesting question."

--- end quoting NIH ---

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