Natural Science Forum / Biology / Biology / September 2006

> a_plutonium wrote:
> > Last night I went to Google search "autism aluminium" and found this
> > website. Below I quoted what I deemed as a sort of "abstract" of what
> > the entire article was discussing. I wanted to try to keep as many of
> > the specific proteins and points of fact and reference in case the
> > website comes down. Unlike the newsgroups which have a quality of
> > permanence, websites can be altered or taken down easily. And for
> > future readers who may want to search deeper would have those
> > references available.
> >
> > Please see my comments below. And I should start a new thread with this
> > article.
> >
> > --- quoting in part (snipped parts)
> > http://www.mothering.com/articles/growing_child/vaccines/toxic.html ---
> > Toxic Overload: Assessing the Role of Mercury in Autism
> > By Boyd E. Haley
> > Issue 115, November/December 2002
> >
> > From 1996 to 1997, J. Curtis Pendergrass, PhD, did some experiments in
> > my research laboratory at the University of Kentucky that confirmed the
> > toxicity of thimerosal in vaccines. The results appeared on our website
> > (www.altcorp.com), where they attracted the attention of some parents
> > of autistic children.
> >
> > These parents informed me that increased mandatory vaccination of
> > infants was, in their opinion, the cause of an apparent epidemic of
> > autism. ...............................snipped
> > .................................................
> >
> > My laboratory was well experienced in mercury research. We had earlier
> > demonstrated that mercury, when exposed to normal human brain tissue
> > homogenates, is capable of causing many of the same biochemical
> > aberrancies found in Alzheimer's diseased (AD) brains.1-4
> > ......................................................snipped
> > ......................................................................................
> >
> > Therefore, we hypothesized that exposure to mercury is involved in the
> > etiology of AD, or at least would exacerbate this disease. We also
> > proposed that other heavy metals, such as lead and cadmium, which act
> > synergistically to enhance the toxicity of mercury, could be involved.
> > Additionally, we proposed that exposure to organic-mercury compounds
> > like methyl mercury from fish and ethyl mercury from thimerosal would
> > also enhance the toxicity of any exposure to mercury. The early work of
> > Dr. Pendergrass confirmed this with pure thimerosal, with some
> > interesting additional observations. First, in human brain samples the
> > exposure to mercury dramatically reduced the viability of a major brain
> > protein called tubulin, but had little if any effect on another major
> > protein, actin. Both tubulin and actin are critically important for the
> > growth of dendrites or maintenance of axon structures of neurons.
> > Exposing neurons to mercury rapidly results in the stripping of tubulin
> > from the axon structure, leaving bare neurofibrils that form the
> > tangles that are the diagnostic hallmark of AD. Thimerosal, like
> > mercury, also rapidly reduces the viability of tubulin; in addition,
> > however, it abolishes the viability of actin. This likely represents a
> > major difference in the mechanism of mercury versus organic-mercury
> > (more neurotoxic) toxicity. However, both mercury and organic-mercury
> > inhibit tubulin viability and would work in concert to damage neurons
> > of the central nervous
> > system..........................................snipped most all of the
> > rest
> > .....................................................................................................
> >
> > NOTES
> > 1. S. Khatoon et al., "Aberrant GTP-Tubulin Interaction in Alzheimer's
> > Disease," Annals of Neurology 26 (1989): 210-215.
> > 2. S. David et al., "Abnormal Properties of Creatine Kinase in
> > Alzheimer's Disease Brain," Molecular Brain Research 54 (1998):
> > 276-287.
> > 3. E. F. Duhr et al., "HgEDTA Complex Inhibits GTP Interactions with
> > the E-Site of Brain-Tubulin," Toxicology and Applied Pharmacology 122
> > (1993): 273-288.
> > 4. J. C. Pendergrass and B. E. Haley, "Mercury-EDTA Complex
> > Specifically Blocks Brain-Tubulin-GTP Interactions: Similarity to
> > Observations in Alzheimer's Disease," in Status Quo and Perspective of
> > Amalgam and Other Dental Materials, International Symposium
> > Proceedings, L. T. Friberg and G. N. Schrauzer, eds., 98-105 (Stuttgart
> > and New York: Georg Thieme Verlag, 1995).
> > 5. J. C. Pendergrass et al., "Mercury Vapor Inhalation Inhibits Binding
> > of GTP to Tubulin in Rat Brain: Similarity to a Molecular Lesion in
> > Alzheimer's Disease Brain," Neurotoxicology 18, no. 2 (1997): 315-324.
> > 6. G. Olivieri et al., "Mercury Induces Cell Cytotoxicity and Oxidative
> > Stress," J. Neurochemistry 74 (2000): 231-241.
> > 7. C. C. W. Leong et al., "Retrograde Degeneration of Neurite Membrane
> > Structural Integrity and Formation of Neurofibillary Tangles at Nerve
> > Growth Cones Following in Vitro Exposure to Mercury," NeuroReports 12,
> > no. 4 (2001): 733-737.
> >
> > Boyd E. Haley, PhD, is a professor and chair of the department of
> > chemistry at the University of Kentucky, Lexington. His research on
> > biochemical aberrancies in Alzheimer's disease led to his identifying
> > mercury toxicity as a major exacerbating factor, perhaps even a causal
> > factor. Haley has testified before numerous government agencies on the
> > effects of mercury toxicity from dental amalgams and vaccines.
> >
> > --- end quoting in parts
> > http://www.mothering.com/articles/growing_child/vaccines/toxic.html ---
> >
> > The above article totally anticipated this post of mine yesterday where
> > I hypothesized Autism as another form of Alzheimers only in different
> > age groups. Only that Dr. Haley did not go so far as to say that Autism
> > is Alzheimers. And I focused on aluminum whereas Dr. Haley focused on
> > mercury.
> >
> > That is an interesting focus, because we know in the 20th century
> > almost every infant was vaccinated and the use of thimerosal was
> > widespread. But also the fact that many old people in the 20th century
> > got flu shots and other shots in old age in which thimerosal was or
> > could have been used. (And perhaps Ronald Reagan got alot of shots,
> > especially in old age).
> >
> > We know there are forms of speeded up Alzheimers and speeded up Prion
> > disease and speeded up Parkinsons. Perhaps the speeding up form was a
> > too large of a dose of vaccine induced. We know that in England in the
> > 19980s or 1990s was a cluster case of Prion disease of young people.
> > Many think it was something they ate in common. But perhaps it was a
> > vaccine that was too high in mercury.
> >
> > Dr. Haley and others have anticipated me by many years, judging that
> > the above was printed in 2002 (sic).
> >
> > But I do bring something new to the table. What I bring is the
> > Methodology that we categorize similar diseases into one large class
> > and from that we can thence say that if such and such is a factor in
> > one of these diseases, then it is likely factor in every other one of
> > those diseases. I have grouped Alzheimers, Prion, Parkinsons and Autism
> > as members of a one group of disease. So that if one of them has a
> > factor of importance, it is likely to be found in the other three. So
> > if a metal is found to cause say Alzheimers, then a metal is probably
> > the cause of Prion, Parkinsons and Autism.
> >
> > That Methodology was discovered by me in the early years of 2000s.
> >
> > Another one of my discoveries is that I know Prion disease is not
> > explained by the Prusiner Model and that model is a fake. But rather,
> > that whatever is the cause of Alzheimers and Parkinsons and Autism is
> > more likely to be the cause of Prion. No-one in the world, not even
> > Prusiner, would venture to say that what causes Alzheimers and
> > Parkinsons and Autism is a rogue protein that misshapes other protein
> > molecules. But rather instead, what every commonsense person would or
> > might say is that some metal in the environment can cause proteins in
> > the brain to go heywire.
> >
> > This thread is already too long and I will start a new thread with much
> > of the above.
>
> In the above report, it spoke of the combination of thimerosal or
> mercury and of aluminium ions as increasing the toxicity, where the
> metals alone are weak in toxicity the combination makes them overly
> toxic. Likewise for other metals such as lead or cadmium. So I wonder,
> since in Prion disease there are a plethora of types of the diseased
> protein, whether the types are due to different amounts of combinations
> of metals. One combination elicits type/form A prion disease and a
> different metal combination elicits type B prion disease, etcetera.
>
> In the above it spoke of the fact that boys seem to catch Autism about
> 4 times as much as girls. An offered explanation was the difference in
> sex hormones of testosterone to estrogen.
>
> So, now, according to my overarching umbrella theory that these
> diseases are all related as a Family GRoup Diseases would imply that
> hormones affect not only Autism but be seen in Alzheimers and Prion and
> Parkinsons. Not to say that they have to have a strict obeyance of a 4
> to 1 ratio. But that some of them would have evidence of hormones
> affecting the male to female contraction rate. So, do we see some
> imbalance between the sexes in Alzheimers? in Prion? in Parkinsons?
>
> If I am not mistaken, it is mostly males that catch Parkinsons. Prion
> is so rare that maybe no marked data is available. As for Alzheimers, I
> am not aware of any imbalance in numbers between male and female. And
> maybe it has something to do with old age, in that the hormones are
> just not "cooking" so to speak in old age as in younger age.
>
> Archimedes Plutonium
> www.iw.net/~a_plutonium
> whole entire Universe is just one big atom
> where dots of the electron-dot-cloud are galaxies