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Natural Science Forum / Biology / Biology / August 2008



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#61 updated TV show "The Forgetting (Alzheimers) ; new book: Metal Causation coupled with Weak-Protein-Point ^Theory of Medicine (Alzheimers, Autism, Parkinsons, Prion, Schizophrenia)

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Archimedes Plutonium - 09 Aug 2008 09:16 GMT
I hope I have my numbers correct, for I have many books ongoing and
hope that this is actually #61.

Tonight in the late hours of the morning I saw this excellent TV
show on PBS of the Alzheimers disease. It is this show that taught
me the basic mechanics of the disease of Alzheimers that the APP
scissors is rogue and cuts the APP protein wrongly, leaving a
small beta amyloid plaque. Actually, the first airing of The
Forgetting showed this mechanism better for in this updated version
it was spoken of by Dr. Tanzi as to this mechanism. Trouble is that
Dr. Tanzi is tilted too far into the idea that Alzheimers is a genetic
disease.

Alzheimers and the other 4 diseases this book covers is caused by metal
or chemical poisons.

I hope researchers start looking and examining the APP scissors as the
essential key to the whole disease. As of this date, everyone seems to
focus on either the beta amyloid plaques or the tau protein buildup.

Logically, it is the APP scissors that should be the central focus.

So what can cause a scissors to become so rogue that it makes bad cuts
in the APP? It is not genetic, but rather, obviously, some chemical
poison. Perhaps some form of a mercury compound. Perhaps mercury in
conjunction with fluoride.

Granted, it was the genetics of chromosome 21 that Tanzi studied that
lead us to the APP scissors. But now is the time to drop the genetics
and focus on the scissors.

This updated version of "The Forgetting" was good in that it relayed
the news of what is called the Pittsburgh Compound that allows us to
actually see the beta amyloid plaques in the brain. Every tool we have
increases our knowledge of what is going on. But now I wonder of several
questions about the Pittsburgh Compound:
(1) Can we design a compound that sticks to the APP scissors?
(2) Has anyone actually retrieved an APP scissors that is rogue and
making those beta amyloid particles? One of the scientist in the show
said these beta amyloids were about the size of two red blood cells
contiguous.

So what I am thinking is that if we can devise another Compound similar
to the Pittsburgh Compound that sticks to the rogue scissors of APP
that we could actually cure the Disease of Alzheimers altogether.

For consider this: that if we can identify rogue APP scissors and then
find a compound that sticks to only rogue scissors and thereby those
scissors could never produce another beta amyloid particle, and whereby
the body cleans out these rogue APP-scissors with the attached Compound.
And further yet, devise another Compound that sticks to the beta amyloid
and flushes it out of the system. So that we made great progress with
the Pittsburgh Compound but it should be utilized further than merely
identification of beta amyloid but actually as a treatment itself. So
the bulk of the labor is to get rid of the rogue APP scissors and then
get rid of the beta amyloid thereby conquering Alzheimers.

Finally, the program mentioned a nice and easy test to tell if one has
Alzheimers. Ask a person if they can spell a word, such as World and
then ask them to spell that word backwards. A normal mind can do that
with almost any word, but an Alzheimers cannot spell backwards.

I expect in the next 5 years when they do a third version of the
Forgetting on PBS TV that this time they will focus on the APP scissors
and focus on what chemicals of the environment for the past 107 years,
where this version told of the history of Dr. Alzheimer treating a Mrs.
Augustin De (spelling) in the year 1901.

Why the sudden huge rise of Alzheimers in the 20th century? Not because
of genetics, but because the increasing rise of some chemical poisons
such as mercury and the overabundance of fluoride in the drinking water.

So take out a rogue APP scissors and find out how it became rogue. Was
it mercury-fluoride or hydrofluoric acid? Or some other chemicals that
turns normal scissors into rogue scissors.

P.S. I also want to make mention of some odd curious fact about
Alzheimers that does not appear in the 4 other diseases listed. The fact
that there seems to be two proteins gone awry in Alzheimers the beta
amyloid and the tau protein. So why two rogue proteins? Is the rogue
APP scissors responsible for the tau protein also? So our research has
not really gone very far into these questions as to why two rogue proteins.

But the TV show is an A+ program that should be continued and updated.

Archimedes Plutonium
www.iw.net/~a_plutonium
whole entire Universe is just one big atom
where dots of the electron-dot-cloud are galaxies
plutonium.archimedes@gmail.com - 09 Aug 2008 18:48 GMT
> I hope I have my numbers correct, for I have many books ongoing and
> hope that this is actually #61.
[quoted text clipped - 80 lines]
>
> But the TV show is an A+ program that should be continued and updated.

I had a look through Google as to the situation of China's Alzheimers,
because if it is
mercury that is making rogue APP-scissors then China should have the
world's highest
rate of Alzheimers. And that is what I found in this BBC report:

--- quoting BBC news ---
That is because she is one of China's six million sufferers of
Alzheimer's. The country now has a third of all Alzheimer's patients
in the world. And the number of diagnosed cases is rising.
--- end quoting BBC news ---

I also worry about the Olympic atheletes at the games of 2008 in
Beijing because all it really takes is
a lungful of mercury to catch Alzheimers.

Also, the rate of Alzheimers in China would not be an easy data to
find as that China would probably
practice euthanasia.

The link between coal fired electric power stations and Alzheimers is
a mighty big link for it implies
that the amount of mercury in the air is what deforms the APP-
scissors.

And, as I have said before, if you look at the regions in the USA
where the air is laden with the most
mercury such as around Utah and Texas, you find the highest rates of
Alzheimers disease.

Archimedes Plutonium
www.iw.net/~a_plutonium
whole entire Universe is just one big atom
where dots of the electron-dot-cloud are galaxies
plutonium.archimedes@gmail.com - 09 Aug 2008 19:03 GMT
(snipped)

> P.S. I also want to make mention of some odd curious fact about
> Alzheimers that does not appear in the 4 other diseases listed. The fact
> that there seems to be two proteins gone awry in Alzheimers the beta
> amyloid and the tau protein. So why two rogue proteins? Is the rogue
> APP scissors responsible for the tau protein also? So our research has
> not really gone very far into these questions as to why two rogue proteins.

On second thought, I do remember reading a report that in Prion
disease there are
a multitude of "forms" of the diseased prion protein. And in
Parkinsons there is more
rogue proteins than simply the alpha synuclein. It is just because in
Alzheimers that
two proteins of a distinct difference are noticed in the disease
process.

So whether the rogue APP-scissors causes both the beta-amyloid
particle and later causes
the tau-protein-particle to form is a question open to research. Is
the rogue APP-scissors
the cause of both the rogue proteins? Perhaps the mercury compound
that causes the
rogue APP-scissors that causes the beta-amyloid-particle connects with
some other chemical
to cause the tau-particle. Is there some metal ion in the beta amyloid
and in the tau-protein for
which the mercury compound deforms?? Our current day research has not
caught up with these
questions.

But in Prion and Parkinsons, there are also more than one rogue
protein involved, and so Alzheimers
is not a divergent oddity as to multiple rogue proteins.

Trouble with all these 5 diseases is that no-one has spent as much
time doing mass spectrography
of mercury poisons, as they have spent time on genetics such as
chromosome 21. If we could
spend more research time on what deforms normal APP scissors into
rogue APP-scissors we would
be getting at the heart of Alzheimers.

Archimedes Plutonium
www.iw.net/~a_plutonium
whole entire Universe is just one big atom
where dots of the electron-dot-cloud are galaxies
plutonium.archimedes@gmail.com - 10 Aug 2008 09:52 GMT
Did some searching around for all the proteins implicated in
Alzheimer, Parkinson and Prion.

Sorry about that, for Parkinson has 3 rogue proteins whereas Alzheimer
has 2 rogue proteins
of beta-amyloid and tau protein.

I was looking for the structure of the APP molecule and the APP-
scissors to see if they contain
copper. Apparently they do.

So what I am getting a preliminary picture of the structure of these
diseases is that all the molecules
involved in Alzheimer, Prion, Parkinson have copper ions as a core
metal ion. We all know blood has
iron as a core metal ion. But it appears that these three diseases of
Alzheimer, Parkinsons and Prion
have copper as their core metal ion.

As for Autism and Schizophrenia, I am not sure of whether there is a
copper ion as the core of
some protein molecule as the basis of those two diseases.

But let me float a preliminary speculative theory that would tie
together all 5 diseases into one
smooth working mechanism of the disease.

We all know that mercury in contact with gold or copper tends to
amalgamate, meaning it binds, or has
an attraction or changes the original shape of the central copper ion.
So could it be that mercury, in
various forms such as ethyl-mercury or methyl-mercury or other toxic
forms that as it enters the brain
can change the "shape or orientation" of the central copper ion in the
various proteins or proteases
of these 5 diseases. Now when the mercury changes the orientation, the
mercury does not remain
with that misshappened protein but moves onwards to encounter more of
those proteins.

So in Alzheimers the mercury may misshappen the APP rather than the
APP-scissors, and either
way, if it misshapes the APP resulting in beta-amyloid stubs or
whether the mercury misshapes the
scissors which then produces the stubs is immaterial becuase either
way there is a creation of unwanted
and unremoval stubs of beta amyloid.

So let me make this rash speculation for it seems to tie everything
together in these 5 diseases. They
all involve some protein gone awry. And we all know mercury can deform
proteins. So my conjecture
here is that mercury deforming the metal ion that is central to the
protein or protease such as copper.
That the mercury via "force of amalgam" causes a deformation or
misshaping of the molecule and which
the body cannot correct that misshappened protein or protease.

The biggest problem I have with the above conjecture is why does not a
person show signs of two
or more of these diseases if mercury is the main culprit? That is a
tough question. If the above is
true, we should have people who have both Parkinsons and Alzheimers
both simultaneously. Maybe
we actually do have such cases. In my readings I found a Alzheimers
called "Swedish mutation" and
I found a Parkinsons called the "Iowan case".  It appears we are
finding more and more of these cases
where we have accelerated Parkinsons or accelerated Alzheimers.
Perhaps what these special cases
are is a convergence of Parkinsons with Alzheimers. And as we find
more exotic cases of these
two diseases we end up with a victim who has both of them
simultaneously.

It is good for me to proffer is overarching conjecture that the
mercury misshapes the copper ion
in these 5 diseases. We all know of sickle cell anemia caused by a
misshappened iron in blood
cells. So when one can offer an idea that answers 5 diseases all at
once, it is best to offer it because it is
rare in science that one mechanism can consolidate 5 disparate
diseases, but since one mechanism
can solve 5 disparate diseases there is a good chance that it is a
true mechanism. It is sort of Occam's
Razor of Logic turned around. That if you see one mechanism that can
explain 5 disparate diseases--
take that plunge of a unification of those disparate 5 diseases for
there is a good chance it is correct--
as Occam would say "a simple mechanism is likely to be true!!"

So here is my conjecture: we have 5 disparate diseases all involving
the brain and we all know mercury
is toxic and damaging to brain tissue and cells and proteins. All 5
diseases have proteins or proteases
and all have copper ions as central metal ions. We all know that
mercury has a force of attraction to
copper called an amalgam-force. So the conjecture is that some form of
mercury deforms proteins or
proteases to cause these 5 diseases.

My toughest challenge is to explain why no person seems to have two or
more of these diseases
simultaneously. There probably have already been such cases but no-one
really payed much attention
to discovering or reporting them. In that PBS show where they showed
some Alzheimers victims, it
appears they have tremors and shaking as what goes on in Parkinsons in
there final stages. Whether
they have Lewy bodies in their brains is unknown to me.

Archimedes Plutonium
www.iw.net/~a_plutonium
whole entire Universe is just one big atom
where dots of the electron-dot-cloud are galaxies
plutonium.archimedes@gmail.com - 10 Aug 2008 21:28 GMT
This is a valid question and a challenge to the theory that mercury
and other metal causation of these
5 diseases. If some poison metal causes these diseases we should
expect some patients to have
a mix of two or more of these diseases. We should have a Parkinsons
showing signs of Alzheimers.
Maybe there are such cases but not reported, not diagnosed, and not
searched for.

In the past, I answered this question by saying there are various
different metals involved and various
different compounds so that Prion disease is cesium-mercury whereas
Alzheimers is mercury-fluoride.

But maybe I can do better.

If we look at these 5 diseases listed we see a pattern. We see that
the earliest of these diseases
is Autism and the next one to appear in victims is Schizophrenia in
the teens and 20's. The
next to appear in a timeline is Parkinsons in the 50's and then Prion
in the 60's and finally
Alzheimers in the 70's. So the five listed diseases are a time
progression of victimization.

So has anyone studied whether Autism and Schizophrenia are related in
terms of frequency of appearance?
Do autistic patients become schizophrenic or a high incidence? Do
Parkinson's patients have a
high frequency of going into Alzheimers? Prion disease is rare, but
has anyone studied whether CJD
goes into Alzheimers?

In this progression timeline of these 5 diseases ---> Autism --->
Schizophrenia ---> Parkinsons --->
Prion ---> Alzheimers

In that progression follows a progression of the brain region
development. Autism is infants and the
region of the brain being developed is the social region of
communicating with others and that is the region
damaged, and then next is schizophrenia and the region being developed
in the brain at teenager and
20s is the neocortex and that is the region damaged by schizophrenia.

So in the progression timeline there is a pattern that the region
being developed in the brain is the region
that mercury would attack.

This suggests to me, that it can be mercury solely as the poisoning
metal. Not that mercury goes to the
region of the brain being developed but that mercury gets lodged into
the DNA/RNA sequencing. Not that
mercury gets lodged into the APP or the APP-scissors but that mercury
gets lodged further upstream in
the actual DNA/RNA sequencing.

So let us say you have a 3 year old and mercury enters their brain,
then it goes and gets lodged into
the DNA/RNA sequencing and the focus of development of a 3 year old is
that part of the brain that
is "social communication" and the mercury inters with that sequencing.
Let us say you have a teenager
who never had any mercury in their body but as a teenager comes in
contact with mercury into the brain.
As a teenager, the DNA/RNA sequencing has long past the "social
development region of the brain" but
is now focused on the neocortex of sequencing-development. So the
mercury gets lodged into the DNA
RNA sequencing and messes-up that development and the aftereffects end
up with schizophrenia.

The same sort of picture emerges with a 50 year old in that mercury
messes up the region where
Parkinsons takes place. Likewise the Alzheimers region for 70 year
olds.

In this fashion, mercury solo can be the cause of all 5 diseases. It
would explain why there are hundreds
of different disease shaped Prion proteins. It would explain why there
are tens to hundreds of proteins
involved in Parkinsons. As far as we know, in Alzheimers there are
only two proteins involved of beta
amyloid and tau-protein, but if one really checks into these two rogue
proteins, they begin to see that
each of them has tens to hundreds of "different versions".

So I used to explain this by saying there are tens to hundreds of
different mercury compounds for there
is ethyl-mercury and methyl-mercury and mercury-fluoride and mercury-
cesium and mercury-rubidium etc etc.

Better yet, as the evidence and data show, that if you lodge, just
simply mercury in the DNA/RNA sequencing
that if this mercury is not dislodged but allowed to influence
whatever is "in focus for the brain to develop"
at that time of the patients life, then the solo mercury can cause all
5 of these diseases.

Here is an analogy of a gang of criminals as mercury and a day as a
lifetime. In the early hours of the
morning say from 1 am to 4 am the criminals are breaking and entering
homes and stealing valuables
(Autism), then from 5 am to 10 am the criminals are robbing people in
the subways and commuter
stations of their purses and wallets (Schizophrenia), then from 11 am
to 3 pm they are robbing banks
(Parkinsons). You catch my drift in this analogy. That solo mercury
lodged in the DNA and RNA sequencing
of the developing human brain from birth to age 70 can unfold these
diseases.

P.S. Still it would be nice to see a report of a person who has two or
more of these diseases
simultaneously, for it would "qualitatively prove the mercury
causation of these diseases".

Archimedes Plutonium
www.iw.net/~a_plutonium
whole entire Universe is just one big atom
where dots of the electron-dot-cloud are galaxies
plutonium.archimedes@gmail.com - 11 Aug 2008 09:18 GMT
Something I should have done before, made a Google search for patients
with concomitant disease.
Using the keywords of-- simultaneous Parkinson Alzheimer I got these
hits:

  1.
     Alzheimer's Symptoms
     www.aricept.com      Learn About Signs & Symptoms. Diagnosis and
Treatment Info.

Search Results
Changes in the brain may link Alzheimer's and Parkinson's diseases
... both Alzheimer's disease and Parkinson's disease, supporting
clinical observations of the simultaneous appearance of symptoms of
both in some patients. ...
www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1172958 - Similar
pages - Note this

The Neurobiology of Parkinsons Disease, part 2: further research ...
Interestingly though, both conditions carry symptoms of dementia.
Recently there have been cases of simultaneous Parkinsons and
Alzheimers symptoms (5). ...
serendip.brynmawr.edu/exchange/node/1697 - 40k - Cached - Similar
pages - Note this

Parkinson Studies Find More Apathy than Depression, Experience ...
Jul 11, 2006 ... Go to more on Alzheimer's, Parkinson & Dementia or
More Senior News on ... Because apathy and depression share some of
the same symptoms, ...
seniorjournal.com/NEWS/Alzheimers/6-07-11-ParkinsonStudies.htm - 59k -
Cached - Similar pages - Note this

Brain changes may link Alzheimer's and Parkinson's diseases ...
Brain changes may link Alzheimers and Parkinsons diseases from British
Medical ... of the simultaneous appearance of symptoms of both in some
patients. ...
findarticles.com/p/articles/mi_m0999/is_7316_323/ai_n27571532 - 42k -
Cached - Similar pages - Note this

Lower urinary tract symptoms in dementia with Lewy bodies ...
Lower urinary tract symptoms in dementia with Lewy bodies, Parkinson
disease, and Alzheimer disease. G. N. Ransmayr, MD, S. Holliger, MD,
K. Schletterer, ...
www.neurology.org/cgi/content/full/70/4/299?maxtoshow=&HITS=25&hits=25&RESULTFOR
MAT=&ando
...
- Similar pages - Note this

Changes in the brain may link Alzheimer’s and Parkinson’s diseases ...
Brain changes may link Alzheimer's and Parkinson's diseases ...
clinical observations of the simultaneous appearance of symptoms of
both in some patients. ...
www.bmj.com/cgi/content/abridged/323/7316/771 - Similar pages - Note
this

The Dana Foundation - A Novel Imaging Approach for Early Diagnosis ...
The distinction between patients with Parkinson's disease who have
concomitant Alzheimer disease, generally known as the Lewy Body
Variant of AD (LBV-AD), ...
www.dana.org/grants/imaging/detail.aspx?id=5886 - 54k - Cached -
Similar pages - Note this

I did not find specific person names with concomitant disease but
apparently there have have quite a
large number of them.

I contend that this is "proof" that mercury is the cause of these 5
diseases. Autism especially is going
through legal court system for having injected mercury as a
preservative in vaccines (thimerosal)
It is a wonder to me, that health organizations and research firms
have spent 50 years and kilograms
of money on everything about Alzheimer, Parkinsons, Schizophrenia,
Prion except looking for atoms
of mercury inside of cells of diseased victims of these diseases.

Truly amazing that we spent 50 years and kilograms of money on these 5
diseases except for looking
for atoms of mercury in the diseased body of victims of these
diseases. And it takes a legal court battle
over Thimerosal to get otherwise educated people to realize that a
deadly poison of mercury is never
safe no matter what the quantity of injection given.

I think every person with a degree in medicine who says mercury is
safe should have their degrees annulled.
I think the national health institutes in the USA who still tout the
safety of thimerosal should have their
degrees annulled as well as being lawsuited. For they abandoned
science and logic long time ago.

When patients appear who have both Prion and Parkinsons concomitantly,
or have Autism and Schizophrenia
concomitantly or have Parkinsons and Alzheimers concomitantly,
signifies the proof evidence that
one chemical poison is behind these 5 diseases.

I would send all the doctors at NIH who ever spoke kindly of
Thimerosal, packing back to school
and learn some logic.

Archimedes Plutonium
www.iw.net/~a_plutonium
whole entire Universe is just one big atom
where dots of the electron-dot-cloud are galaxies
plutonium.archimedes@gmail.com - 11 Aug 2008 21:13 GMT
Now I was looking today for a website that describes a patient who has
Autism and has simultaneously
the "early onset Alzheimer's". I found no names of a person who has
both autism and early onset
Alzheimer's although some websites "hint" of there being such cases.

I did find this website:

http://townmusician.blogspot.com/2008/03/alzheimers-autism-connection.html

Saturday, March 08, 2008
Birgit Calhoun

--- quoting a paragraph of that blogspot ---
The good version contains the most sulfur. The bad version doesn't
contain any. It is known that
mercury loves sulfur.

Autism and Alzheimer's might be caused by mercury poisoning. Carrying
the thought a little
further, it is known that those ApoEnzymes are the only enzymes that
can transport mercury
out of the brain so it can be excreted.
--- end quoting that blogspot ---

I quoted that because it harmonizes with my recent statement of how
mercury as the solo cause of
all 5 diseases, how the mercury can cause these 5 diseases depending
on the stage of life the victim
is in. If a person is 2 years old and gets a dose of mercury, then it
translates into Autism. If a person
is a teenager and gets a dose of mercury, it is not Autism that
results but Schizophrenia. If a person
is in 50's and gets a dose of mercury the result is not Autism nor
Schizophrenia but Parkinsons. All the
way up to Alzheimers.

So in the above paragraph we can see how doses of mercury at various
stages of life of a person
can bring forth one of those 5 diseases.

So when I want to picture a mechanism of how solo mercury can cause 5
diseases in the developing
brain from birth to age 70's, it is a mechanism of mercury tearing out
sulfur and the brain unable to
remove that mercury because the mercury destroys the removal-proteins.
And there is a link between
the developing regions of the brain. In infancy, mercury would destroy
the speech centers. In teenager
years the mercury would destroy neocortex connections and result in
schizophrenia.

In old age, the mercury would attack either one of these three
centers--- Parkinson, CJD or Alzheimer.

In medicine, up to this moment, we viewed those three diseases as
different and distinct. But with
mercury as the solo cause, we can say that Parkinson is a form of
Alzheimer and that Prion disease
is a form of Alzheimers. In old age, where the mercury attacks the
brain is any number of sites all
leading to deformation of proteins. Does it matter if the mercury
deforms beta amyloid or tau or alpha
synuclein or Lewy bodies or prion proteins? No, it really does not
matter because it is all due to
the presence of mercury in the brain causing the deformations.

The medical literature is swamped by reports of genetic causes. This
is a pitiful shame, since these
five diseases are not genetically caused. If the world had no mercury
entering human bodies, none of
these 5 diseases would exist. The genetic influence is that families
usually have a higher risk of eating
mercury fish or mercury vaccines or mercury tooth fillings or
breathing coal fired mercury air near their
homes. Plus a family is likely to have the same body reaction to the
ingested or inhaled mercury.

So medicine has to begin to revert this massive misguided "genetic
basis" for these 5 diseases. It is not
genetics. It is mercury poisoning. Instead of wasting another 50 years
and money on genetic research
we must now begin to apply chemical analysis of mercury in brain
tissue and brain cells. Instead of
millions of reports to journals on some genetics of these 5 diseases
we need reports of mass spectroscopy
on mercury atoms inside of cells of the brain.

Archimedes Plutonium
www.iw.net/~a_plutonium
whole entire Universe is just one big atom
where dots of the electron-dot-cloud are galaxies
Archimedes Plutonium - 12 Aug 2008 09:45 GMT
What is going on with sci.med that Google does not recognize it?

Here is a website of an abstract from Japan of a woman who had both
Parkinson and Prion diseases
simultaneously.

http://www3.interscience.wiley.com/journal/118980175/abstract?CRETRY=1&SRETRY=0

As I noted earlier, if mercury is the root cause of these 5 diseases
then slowly but surely we should see
cases of where victims of two or more of these diseases simultaneously.
The most prevalent ones should
be where the transition ages are close together so that a dosage of
mercury would start the onset of
two nearby-aged diseases such as Parkinson's and Prion, or Prion and
Alzheimers.

The most difficult concomitant cases would be Autism simultaneously
Alzheimers. It is more likely
for Autism simultaneous with Parkinsons or especially Autism
simultaneously with Schizophrenia.

Archimedes Plutonium
www.iw.net/~a_plutonium
whole entire Universe is just one big atom
where dots of the electron-dot-cloud are galaxies
 
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