What is Irreducible Complexity?
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ceb_luv_lotr - 03 Mar 2006 18:10 GMT Irreducible Complexity is a term invented and used by modern Biochemists to explain the complexity of the cell and how all the parts work together. In order for the cell to produce the function it needs to every single part is essential. One of the most common ways that Irreducible Complexity is used is in the flagellum on some kinds of single-celled bacteria. The flagellum on the bacteria appears to most like a whip spinning in circles in order to propel this single-celled organism into the direction it needs to go. With the use of this simple "tail", the bacteria can easily move forward and backward going up to three times it's own body length in a second. The flagellum can also very quickly stop and change directions at any time. When looking at the bacteria's flagellum from the outside, we can see the filament looking like a long tail, and the hook which attaches the filament to the bacteria. When looking underneath the surface we then see that the hook is attached to an L ring and a P ring. These are then attached to an S ring and an M ring surrounded by a C ring and a ring of studs. All of this--S ring and M ring (rotor), studs and C ring (stator), L ring and P ring (bushing)--are held in place by the membrane that surrounds the cell. If one of these parts is missing, the entire flagellum does not work. All that happens is the filament lies dead. Pointless, useless, giving the single-celled organism a huge weight at one end and no way to move.
Resources: - http://www.millerandlevine.com/km/evol/design2/article.html - www.arn.org/docs/ mm/flag_labels.htm - "Unlocking the Mystery of Life" (video) www.illustramedia.com
Mark VandeWettering - 03 Mar 2006 18:15 GMT ["Followup-To:" header set to talk.origins.]
> Irreducible Complexity is a term invented and used by modern > Biochemists to explain the complexity of the cell and how all the parts > work together. Actually, one biochemist. And not a very good one.
[ snipped the description of the harbinger of God's glory, the bacterial flagellum ]
Hallelujah!
Mark
Noone Inparticular - 03 Mar 2006 18:17 GMT > Irreducible Complexity is a term invented and used by modern > Biochemists to explain the complexity of the cell and how all the parts > work together. Wow. One sentence at least six errors. Amazing.
<snip rest>
Grandbank - 04 Mar 2006 04:25 GMT > Wow. One sentence at least six errors. Amazing. Creationists revel in ignorance. They wallow in it. They fling it in the air, and rub it on themselves like demented monkeys that have just discovered the latrine at a banana eating contest.
Ken Phelps
Matt Silberstein - 03 Mar 2006 18:21 GMT >Irreducible Complexity is a term invented and used by modern >Biochemists to explain the complexity of the cell and how all the parts >work together. Wow, is that deceptive. It is a term invented and used by *a* (one, 1, singular, solitary) biochemist by the name of Behe. It explains nothing, it is just sort of an assertion, a classification.
>In order for the cell to produce the function it needs >to every single part is essential. That is *not* the claim that Behe makes. Which is good because it is even more wrong than his claims.
>One of the most common ways that >Irreducible Complexity is used is in the flagellum on some kinds of >single-celled bacteria. Common as in the primary way Behe uses to obfuscate (almost the opposite of explain) in his book.
>The flagellum on the bacteria appears to most like a whip spinning in >circles in order to propel this single-celled organism into the [quoted text clipped - 13 lines] >dead. Pointless, useless, giving the single-celled organism a huge >weight at one end and no way to move. Which is not an explanation and not an argument and says nothing about evolution.
>Resources: >- http://www.millerandlevine.com/km/evol/design2/article.html >- www.arn.org/docs/ mm/flag_labels.htm >- "Unlocking the Mystery of Life" (video) www.illustramedia.com Did you even bother to look at Behe' book?
 Signature Matt Silberstein
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Elf M. Sternberg - 03 Mar 2006 18:36 GMT > Irreducible Complexity is a term invented and used by modern > Biochemists to explain the complexity of the cell and how all the > parts work together. The concept of Irreducible Complexity is ignored or rejected by the majority of the scientific community. This rejection stems from the following: the concept utilises an argument from ignorance, Behe fails to provide a testable hypothesis, and there is a lack of evidence in support of the concept. As such, Irreducible Complexity is seen by the supporters of evolutionary theory as an example of creationist pseudoscience, amounting to a God of the gaps argument.
Niall Shanks and Karl H. Joplin have shown that systems satisfying Behe's characterization of irreducible biochemical complexity can arise naturally and spontaneously as the result of self-organizing chemical processes. They also assert that what evolved biochemical and molecular systems actually exhibit is redundant complexity-- a kind of complexity that is the product of an evolved biochemical process. They claim that Behe overestimated the significance of irreducible complexity because his simple, linear view of biochemical reactions results in his taking snapshots of selective features of biological systems, structures and processes, while ignoring the redundant complexity of the context in which those features are naturally embedded and an overreliance of overly simplistic metaphors such as his mousetrap. In addition, it has been claimed that computer simulations of evolution demonstrate that it is possible for irreducible complexity to evolve naturally.
Elf
Ray - 04 Mar 2006 07:53 GMT >Niall Shanks and Karl H. Joplin have shown that systems satisfying >Behe's characterization of irreducible biochemical complexity can arise >naturally and spontaneously as the result of self-organizing chemical >processes. What is evolutionary possible at one level of complexity is not necessarily possible at higher levels. For each level of complexity, the improbability of something specific happening by random mutation increases exponentially. There is quite a step between self-organizing chemical processses and a flagellum.
Also, adaptability and compatibility between merging subsystems decreases drastically with increasing complexity and specificness.
Robert Carnegie - 04 Mar 2006 11:59 GMT > >Niall Shanks and Karl H. Joplin have shown that systems satisfying > >Behe's characterization of irreducible biochemical complexity can arise [quoted text clipped - 9 lines] > Also, adaptability and compatibility between merging subsystems > decreases drastically with increasing complexity and specificness. Blabble. "specificness" isn't even a word.
BarryAC - 04 Mar 2006 12:34 GMT re "specificness". Neither was "normalcy" a word, but it seems to have taken the place of "normality". I trust no-one will cite this as an example of evolution. Barry AC.
Tim K. - 04 Mar 2006 21:22 GMT >>Niall Shanks and Karl H. Joplin have shown that systems satisfying >>Behe's characterization of irreducible biochemical complexity can arise [quoted text clipped - 6 lines] > increases exponentially. There is quite a step between self-organizing > chemical processses and a flagellum. Ah, probability. This morning the temperature was 60. By noon it was 76. What is the probability that at some point in time today it was 70 degrees?
> Also, adaptability and compatibility between merging subsystems > decreases drastically with increasing complexity and specificness. That doesn't even make sense.
Friar Broccoli - 05 Mar 2006 01:02 GMT >> Niall Shanks and Karl H. Joplin have shown that systems >> satisfying Behe's characterization of irreducible biochemical >> complexity can arise naturally and spontaneously as the result >> of self-organizing chemical processes. [... snipped ....]
> For each level of complexity, the improbability of something > specific happening by random mutation increases exponentially. While this appears plausible, a bit of consideration shows the opposite is almost certainly true in practice. The organisms that existed 3.7 billion years ago were so extremely simple that they didn't have a lot to work with. But over hundreds of millions of years they gradually developed all sorts of little bits and pieces like: improved membranes, ion transport mechanisms, skeletons, shells, hairs, fins, nervous system, magnetic, vibration, chemical and light sensors etc etc.
Each of these subunits can be looked at like one part of a Lego set, or module that can be combined with another modules to make something new and interesting. Thus with a larger tool kit evolution can proceed much faster.
Indeed looking at the fossil record this appears to be exactly what happened. Up until about a billion years ago not a lot appeared to be happening, and not very fast. Then we started seeing more types of cells. For example we first see a calcium shelled amoeba at about 750 million years (in the Grand Canyon), then at about 590 million years we see the first traces of multicellular organisms probably early ancestors of Jellyfish and sponges (at Doushantou in China)
At about 530 million years we have evidence of the first jointed animals, with the first Trilobite making its entrance at 520 million years, by which time, we find what appear to be representatives of all modern groups, although we are still a very long way from seeing land plants and animals.
So, in summary for the first 3 billion years we don't see much happening. Things start getting interesting at about 750 million years and then pandemonium breaks out with the beginning of the Cambrian at 540 million years. Sadly, I must inform you that the last Trilobite cast off its earthly burden about 250 million years ago. But it put on a good show, having spawned more than 15,000 species in the intervening 270 million years.
So, in short, the fossil record appears to tell us that evolution accelerates as creatures accumulate more and developmental subunits or modules.
> There is quite a step between self-organizing chemical > processses and a flagellum. John Harshman's post pointed to a detail description of how it might be done:
http://www.talkdesign.org/faqs/flagellum.html
And my main response contained a much simplified description of how it might occur:
http://groups.google.com/group/talk.origins/msg/46d1c15a3a8d22a7
If after reading them, you remain unconvinced, I would be happy to discuss the question further with you.
> Also, adaptability and compatibility between merging subsystems > decreases drastically with increasing complexity and specificness. As my description of the fossil record above mentioned, the subsystems are better viewed as modules, which evolutionary processes can use as a tool kit to increase the rate of development.
Cordially;
Friar Broccoli Robert Keith Elias, Quebec, Canada Email: EliasRK (of) gmail * com Best programmer's & all purpose text editor: http://www.semware.com
--------- I consider ALL arguments in support of my views ---------
TomS - 03 Mar 2006 18:54 GMT "On 3 Mar 2006 10:10:47 -0800, in article <1141409447.677945.35170@i39g2000cwa.googlegroups.com>, ceb_luv_lotr stated..."
>Irreducible Complexity is a term invented and used by modern >Biochemists to explain the complexity of the cell and how all the parts [...snip...]
The concept of "irreducible complexity" long predates its use as an anti-evolutionary argument.
I've seen it used as early as 1712, as an argument against the development of the embryo, and for the pre-existence of each individual living thing (created, individually, back at the beginning).
This is just another example of a complaint which is advertised as being anti-evolution, but - quite aside from whether it is a good argument - is better recognized as having something like development as its target.
(Of course, development is real - just as real as evolution - so the complaint must have some fatal flaw.)
 Signature ---Tom S. <http://talkreason.org/articles/chickegg.cfm> "It is not too much to say that every indication of Design in the Kosmos is so much evidence against the Omnipotence of the Designer. ... The evidences ... of Natural Theology distinctly imply that the author of the Kosmos worked under limitations..." John Stuart Mill, "Theism", Part II
Cubist - 03 Mar 2006 18:55 GMT [snippage]
> Irreducible Complexity is a term invented and used by modern > Biochemists to explain the complexity of the cell and how all the parts > work together. "Explain the complexity of the cell"? Hmmm... no, I disagree. Irreducible Complexity isn't an *explanation* of "anything*; rather, IC is a quality that some pieces of the machienry of life are supposed to have. "The flagellum is IC" is no more an *explanation* of *anything* than, say, "The sky is blue" or "Water is wet". Rather, "The flagellum is IC" is, at best, an *observation*, and perhaps an observation which *needs* an explanation -- but that observation, in and of itself, is *not* an explanation.
> In order for the cell to produce the function it needs > to every single part is essential. Ah; I see that you accept Behe's definition of Irreducible Complexity. Dembski has a rather different definition for Irreducible Complexity; if I may ask you, on what grounds do you accept Behe's version of IC over Dembski's version of IC?
> One of the most common ways that > Irreducible Complexity is used is in the flagellum on some kinds of > single-celled bacteria. ... Okay, fine, the flagellum is IC. So what? If you mean to imply "IC, therefore Designed and not evolved", it's worth noting that *by (Behe's) definition*, an IC system is one which stops working the moment *any* of its parts breaks -- in other words, an IC system is *brittle*. Not robust at all. Fragile and vulnerable, even. Imagine, if you will, that you're behind the wheel of an IC automobile. There you are, driving down the highway, when suddenly the engine dies! You of course step on the brake and steer towards the side of the road, but -- alas! -- the brakes *and* steering *both* died with the engine. You try to put your hazard lights on, but only succeed in adding "hazard lights" to the growing list of functions which stopped working when the engine died. Fortunately, everyone else on the road manages not to collide with your disabled hulk of a vehicle, so you survive to (eventually) learn what the heck *happened* which *made* your vehicle a disabled hulk: A fuse burned out. Since your vehicle *was* IC, and an IC system is one for which *all* parts *must* be functional in order for the the system to work... well, *everything* stopped working. Thus, to the extent that IC actually does imply a Designer, it implies that this Designer isn't especially *competent*... The competence of the Designer isn't a problem for evolution, of course. Neither is IC -- one general evolutionary pathway to IC is to start with a *non*-IC system and lose parts of it until what's left *is* IC.
CreateThis - 03 Mar 2006 20:48 GMT > Irreducible Complexity is a term invented and used by modern > Biochemists to explain the complexity of the cell and how all the parts [quoted text clipped - 22 lines] > Resources: > - http://www.millerandlevine.com/km/evol/design2/article.html Why do you suppose the trollbot added Miller's *rebuttal* of the IC argument as a 'resource'?
CT
ceb_luv_lotr - 03 Mar 2006 21:23 GMT Ok, I appologize. I am not perfect and do not know everything.
Can we please cut back on the rude and sarcastic comments? (ex--"...but really that post was bad, bad, badly bad." -Noone Inparticular) especially since you need to remember that the people who write these posts read them also. You can argue your points all you want, that's wonderful! That's what I want. Just please do not do it in a way that is hurtful.
Also, please know that I was not trying to argue Intelligent Design or Creation. I was merely trying to answer a question that was asked somewhere else and had a poor answer attached to it.
Again, I appologize for not knowing everything about this. I'm working on learning more.
Thank you :)
Noone Inparticular - 03 Mar 2006 21:45 GMT > Ok, I appologize. I am not perfect and do not know everything. I apologize as well. You appear to not be an IDiot, just someone unfamiliar with the routine here at T.O. No shame in that. Next time, make an effort to be up front about your intentions. It'll help stop knuckleheads like me from jumping all over you.
> Can we please cut back on the rude and sarcastic comments? (ex--"...but > really that post was bad, bad, badly bad." -Noone Inparticular) Uh huh. Again, sorry. But you'd be amazed at the inanity we see here on a daily basis. Look at the recent "Loon Census" thread, pick any name out of the starting lineup and read some of their posts. Have a barf bag handy.
> especially since you need to remember that the people who write these > posts read them also. You can argue your points all you want, that's [quoted text clipped - 7 lines] > Again, I appologize for not knowing everything about this. I'm working > on learning more. Good on you. Keep doing that.
> Thank you :) BarryAC - 03 Mar 2006 21:54 GMT Browsing the websites on both sides of the debate (I too am new to this surfing) I notice that emotive reactions are mostly from the evolutionists, spoiling what could be, like this thread, a balanced and informative discussion. Of course there are crazies amongst the creationists (notice my gaff earlier re "R. Dawkins"), but far better to ignore all of them, on both sides, than respond with "who can say the craziest thing!" Keep sane, keep calm, God bless us all. Barry AC.
Ray - 04 Mar 2006 08:13 GMT >Browsing the websites on both sides of the debate (I too am new to this >surfing) I notice that emotive reactions are mostly from the evolutionists, >spoiling what could be, like this thread, a balanced and informative >discussion. Yea, I've noticed that too. It doesn't exactly increase people's credibility to use such "arguments".
Ken Shaw - 05 Mar 2006 03:34 GMT > >Browsing the websites on both sides of the debate (I too am new to this > >surfing) I notice that emotive reactions are mostly from the evolutionists, [quoted text clipped - 3 lines] > Yea, I've noticed that too. It doesn't exactly increase people's > credibility to use such "arguments". It always amazes me when some creationist shows up, spouts the same old tired disproven arguments, dumps a little ad hominen and then claims that the other side is mean spirited. On those rare occasions when a creationist himself isn't hurling insults with every post they completely ignore the failings of their own side when chastising the other.
I'm sure the supporters of science will tone down the insults etc. when the creationist stop trying to blame the Holocaust, Communism and every other perceived evil of modern history on the ToE; stop claiming that you can't be christian if you accept the ToE; posting the same old tired drivel that AiG said years ago your side should stop using; cease filling up many kbytes of bandwidth with self refential posts; actually read evidence when it is presented and make an honest effort to understand it and finally stop hurling insults at the other side.
Ken
BarryAC - 05 Mar 2006 11:36 GMT To Ken. "Touche'!" As I have said before, most posts in this group are in the conflict arena, but there are other arenas in which to hold this debate (science/religion interface, as I like to call it. Creationism/evolutionism invites a war of ideologies). Sorry no reference yet, but M. Poole of King's College London has done much work on this. Barry AC.
Tim K. - 05 Mar 2006 12:19 GMT > I'm sure the supporters of science will tone down the insults etc. when > the creationist stop trying to blame the Holocaust, Communism and every [quoted text clipped - 6 lines] > > Ken What he said!
explainer - 03 Mar 2006 23:07 GMT > Ok, I appologize. I am not perfect and do not know everything. > [quoted text clipped - 4 lines] > wonderful! That's what I want. Just please do not do it in a way that > is hurtful. If you can't take playing with the big boys you may want to try another group like talk.nothing
You may also benefit from the attitude that "what you think of me and my ideas is none of my business."
I have learned more for the less than gentle intellects here than the marshmallows. Gird up your emotional loins and wade in.
> Also, please know that I was not trying to argue Intelligent Design or > Creation. I was merely trying to answer a question that was asked > somewhere else and had a poor answer attached to it. > > Again, I appologize for not knowing everything about this. I'm working > on learning more. Why don't you know everything about this? There are several who do (not me). I'm like Sgt. Schultz, "I know nothing, nothing."
Hang in there. It doesn't hurt to insert qualifiers when you are uncertain. Asking a question is a good move.
I started a post on the origin of species with a really dumb example (and got nailed for it), but I also got more instruction than I could comprehend, almost more than my teeny tiny intellect could endure.
It's at http://groups.google.com/group/talk.origins/browse_frm/thread/b9c8f31a2225d091/3 b4a380f3c44ee8a?lnk=st&q=&rnum=34#3b4a380f3c44ee8a
I offer this as an example of what can happen when I get my ego out of the way and seek new knowledge.
Also, some of the posters are real leg pullers. You never know when someone is trying to scald you and when they are just having some fun. (Well, you do know with some of them who have no sense of humor and see themselves as the axis mundi of universal knowledge.)
All the best, Gordon Hill
CreateThis - 04 Mar 2006 02:02 GMT > Ok, I appologize. I am not perfect and do not know everything. > [quoted text clipped - 13 lines] > > Thank you :) Explanation-free regurgitation of common, lame and nonsensical antievolution arguments is exactly what nutcase antievolutionist trolls do here every day. Maybe you aren't one, but everything you've done so far fits.
CT
Friar Broccoli - 05 Mar 2006 22:01 GMT > > Ok, I appologize. I am not perfect and do not know everything. > > [quoted text clipped - 13 lines] > > > > Thank you :)
> Explanation-free regurgitation of common, lame and nonsensical > antievolution arguments is exactly what nutcase antievolutionist trolls > do here every day. Maybe you aren't one, but everything you've done so > far fits. I just found this post by "ceb_luv_lotr":
http://groups.google.com/group/sci.bio.paleontology/msg/112816f9468a9537
I believe it conclusively contradicts the "fit".
Cordially;
Friar Broccoli Robert Keith Elias, Quebec, Canada Email: EliasRK (of) gmail * com Best programmer's & all purpose text editor: http://www.semware.com
--------- I consider ALL arguments in support of my views ---------
Friar Broccoli - 04 Mar 2006 02:31 GMT [... most of message snipped ...]
> If one of these parts is missing, the entire flagellum does > not work. All that happens is the filament lies dead. > Pointless, useless, giving the single-celled organism a huge > weight at one end and no way to move. There is one very large problem with Behe's argument. It implies that the flagellum popped into existence complete and ready to fulfill its current function. This is not how the evolution of complex devices like the eye or flagellum are thought to occur.
Rather they are thought to be created gradually as parts which were initially used for OTHER purposes are gradually accumulated by the organism over many millions of years of evolution.
The flagellum is basically a hole, a rotating doorway around the hole, and a tube sticking through the hole which is rotated by the enclosing doorway.
- The hole is obviously not a problem. If bacteria didn't have holes they couldn't "eat" or remove waste or eject poison etc.
- The hollow shaft sticking out of the hole is just as obviously not a problem. It could have evolved as a type of foot, or stem for holding onto things. Maybe it was used as a spear for sticking into other bacteria to kill them and suck out the contents etc. Stick like appendages have all sorts of interesting uses, so lots of different types would have evolved in lots of different ways.
- So that leaves the rotating bit, and as it turns out, that's not a problem either. Most cells already have rotating doorways to help transfer things across cell walls.
So its just a matter of coupling together the shaft with a rotating doorway, a relatively minor mutation. Initially the rotation would have been very inefficient, but 2 billion years ago (or whenever flagellum started to evolve) nothing had a good moveable arm/stick/flagellum so any bacteria that had even a poorly functioning one would have had an advantage over his completely stationary neighbours.
After that you just add a billion years of evolution (bacteria have been evolving for more than 3 billion years) and you get the insanely beautiful flagellum that we see today.
It is true that if you took out any part TODAY, the current version wouldn't work at all, but it got that way via lots of small changes over a very long period of time.
And remember, we've got about 1,000,000,000,000,000,000,000,000,000,000 bacteria on earth right now and each day or so most of them will divide, and a lot of them will have a small mutation that may improve their performance. Over billions of years, that many bacteria working that hard are bound to accomplish some interesting stuff.
I hope this helps clarify things for you.
Cordially;
Friar Broccoli Robert Keith Elias, Quebec, Canada Email: EliasRK (of) gmail * com Best programmer's & all purpose text editor: http://www.semware.com
--------- I consider ALL arguments in support of my views ---------
anon1@sci.sci - 04 Mar 2006 04:21 GMT <http://groups.google.com/group/talk.origins/msg/46d1c15a3a8d22a7> = Message-ID: <1141439483.876961.119310@i40g2000cwc.googlegroups.com>
> The flagellum is basically a hole, a rotating doorway around > the hole, and a tube sticking through the hole which is > rotated by the enclosing doorway.
> - The hole is obviously not a problem. If bacteria didn't have > holes they couldn't "eat" or remove waste or eject poison > etc.
> - The hollow shaft sticking out of the hole is just as > obviously not a problem. It could have evolved as a type of [quoted text clipped - 3 lines] > sorts of interesting uses, so lots of different types would > have evolved in lots of different ways.
> - So that leaves the rotating bit, and as it turns out, that's > not a problem either. Most cells already have rotating > doorways to help transfer things across cell walls.
> So its just a matter of coupling together the shaft with a > rotating doorway, a relatively minor mutation. Initially the [quoted text clipped - 3 lines] > had even a poorly functioning one would have had an advantage > over his completely stationary neighbours.
> After that you just add a billion years of evolution > (bacteria have been evolving for more than 3 billion years) > and you get the insanely beautiful flagellum that we see > today. That's the best rebuttal I've read in a long time. I cited the GGURL and message-ID in case somebody wants to link it from one of the FAQs, and I quoted the whole good part so more people would chance to see it.
> It is true that if you took out any part TODAY, the current > version wouldn't work at all, ... Actually depending on what part you took out, it might still work, not the same as with all parts, maybe not the same function at all, but some other function might still occur. So I didn't include that in the "best rebuttal" quote above. .
Friar Broccoli - 04 Mar 2006 16:21 GMT > That's the best rebuttal I've read in a long time. Thanks.
Cordially;
Friar Broccoli Robert Keith Elias, Quebec, Canada Email: EliasRK (of) gmail * com Best programmer's & all purpose text editor: http://www.semware.com
--------- I consider ALL arguments in support of my views ---------
Noone Inparticular - 04 Mar 2006 16:29 GMT > [... most of message snipped ...] > [quoted text clipped - 20 lines] > holes they couldn't "eat" or remove waste or eject poison > etc. Erm, Brother Vegetable, don't confuse the lad. If bacteria really had holes in their membranes they be dead. They'd be unable to maintain ion gradients, required for life. Better to say "pore" rather than hole as a pore has a closure that prevents the equilibration of the salts in the cytosol with the envrionment while still allowing things to pass through the membrane.
Didactically yours
NI
> - The hollow shaft sticking out of the hole is just as > obviously not a problem. It could have evolved as a type of [quoted text clipped - 41 lines] > > --------- I consider ALL arguments in support of my views --------- John Harshman - 04 Mar 2006 17:49 GMT >>[... most of message snipped ...] >> [quoted text clipped - 27 lines] > the cytosol with the envrionment while still allowing things to pass > through the membrane. Hmmm. If that's true, then what am I doing when I make competent bacteria for cloning? I always thought I was putting little holes in their cell membranes.
Ever more didactically yours.
[snip]
Noone Inparticular - 04 Mar 2006 22:08 GMT > >>[... most of message snipped ...] > >> [quoted text clipped - 31 lines] > bacteria for cloning? I always thought I was putting little holes in > their cell membranes. I don't know which method you use, but some of the most popular methods don't involve making holes in cell membranes (cationic lipids and cationic precipitation) and the most commonly used method that does put holes in cell membranes, electroporation, results in holes whose existence is measured in milliseconds. Far to short a time for diffusion of salts, but more than adequate for transfer of nucleic acids.
When you are facing a bacterial infection in your body, one of the most effective inate mechanisms to kill the infection results from the formation of stable perforations in the cell membranes. The complex of proteins which does it, perforin, is the product of the complement system. The stable perforations make it impossible for the cell to control the concentrations of salts within it, thus killing the cells.
How's THAT for didactic?
> Ever more didactically yours. > > [snip] John Harshman - 04 Mar 2006 22:48 GMT >>>>[... most of message snipped ...] >>>> [quoted text clipped - 40 lines] > diffusion of salts, but more than adequate for transfer of nucleic > acids. Oh. There's a perfect demonstration that its not necessary to know what you're doing in order to do biology. I follow the recipe, I get clones, I sequence the clones. All fine, and no need to know why it works.
> When you are facing a bacterial infection in your body, one of the most > effective inate mechanisms to kill the infection results from the [quoted text clipped - 8 lines] >> >>[snip] Noone Inparticular - 05 Mar 2006 21:36 GMT > >>>>[... most of message snipped ...] > >>>> [quoted text clipped - 44 lines] > you're doing in order to do biology. I follow the recipe, I get clones, > I sequence the clones. All fine, and no need to know why it works. You're quite right; much of the business end of many techniques are not really well understood, even by the people who develop them. Since I can't seem to avoid being didactic in this thread, I might as well go on.
It appears that what happens with many of the protocols that use cationic salts is that if the salt and nucleic acid concentrations are right, meta-stable complexes between the nucleic acids and salts form. These complexes mask the net charge on the nucleic acid and since in the complexes they are essentially non-polar, they precipitate. The insoluable and partially soluble somewhat non-polar complexes are able to get across the cell membrane because those high salt conditions also greatly alter surface dilution kinetics of the membrane. Since they are largely non-polar in the meta-stable complex, they can diffuse through the membrane.
With the cationic lipids, it much more straight forward; the cationic headgroups of the lipids bind the phosphate groups on the nucleic acids, masking both molecules charges. The non-polar acyl chains do the rest.
> > When you are facing a bacterial infection in your body, one of the most > > effective inate mechanisms to kill the infection results from the [quoted text clipped - 8 lines] > >> > >>[snip] Friar Broccoli - 04 Mar 2006 20:25 GMT >> - The hole is obviously not a problem. If bacteria didn't have >> holes they couldn't "eat" or remove waste or eject poison >> etc.
> Erm, Did you mean Om?
> Brother Vegetable, Thanks for acknowledging that we are commonly decent.
> don't confuse the lad. I try to do that by avoiding unimportant technical details.
> If bacteria really had holes in their membranes they be dead. > They'd be unable to maintain ion gradients, required for life. > Better to say "pore" rather than hole as a pore has a closure > that prevents the equilibration of the salts in the cytosol > with the envrionment while still allowing things to pass > through the membrane. I get the impression that ceb_luv_lotr has limited knowledge in biology, consequently, I believe that the use of the word "pore" would have added to the confusion, by making an already complex message just a little bit harder to access.
Also, I'm not even certain I am technically wrong, since a "pore" is (I believe) simply a hole that is normally closed.
And if I'm wrong about that it appears that John Harshman is ready to beat up on you. So I must ask if your cause has aids?
That said, I debated with myself about adding my usual "I am an idiot" disclaimer. Still don't know if I should have.
> Didactically yours That word has too many syllables for use in polite conversation.
Yours in the holey Broccoli
Friar Broccoli Robert Keith Elias, Quebec, Canada Email: EliasRK (of) gmail * com Best programmer's & all purpose text editor: http://www.semware.com
--------- I consider ALL arguments in support of my views ---------
anon1@sci.sci - 04 Mar 2006 03:31 GMT > Irreducible Complexity is a term invented and used by modern > Biochemists to explain the complexity of the cell and how all the parts > work together. No, it's a term invented by drop-outs who didn't happen to show up for class the day of the lecture on "scaffolds" and change of function over time.
> In order for the cell to produce the function it needs to every > single part is essential. Are you talking about the basic essential functions (growth and replication) needed by every cell, or the complete set of specific functions a particular cell happens to have currently, which have undoubtedly changed many times over the ancestral history of that cell?
The basic functions have been the same for at least 3.5 billion years, carrying us back through the RNA-to-DNA takeover and all the way to the start of RNA world and probably even earlier. So the fact we can't quite see how they could exist without each other is no problem for evolutionary theory.
The complete set of incidental functions don't have IC, so if that's what you meant then you are flat-out liar.
> The flagellum on the bacteria ... How does this relate to IC? Some bacteria have flagella, and some get by just fine without them. They are in no way essential to life.
> If one of these parts is missing, the entire flagellum does not work. Maybe the thing as a whole doesn't work in the current way, to provide largescale motion through the water, but the remaining parts still work in other ways, such as by pumping waste out of the cell.
> All that happens is the filament lies dead. Pointless, useless, > giving the single-celled organism a huge weight at one end and no way > to move. Well if the part that makes the flagellum spin was broken, but the bulk of the filament was still there, sure. But what if the bulk of the flagellum was the part that was missing, or greatly shortened, and the tiny base still spun just fine? Then the cell wouldn't have the problem you cite. There are in fact some niches where that partial system is optimal, and we see some cells adapted to that niche even today.
Why do you waste your typing energy beating this same dead horse again? .
Ray - 04 Mar 2006 06:04 GMT Quote:
"Anyone can state at any time that they cannot imagine how evolutionary mechanisms might have produced a certain species, organ, structure. Such statements, obviously, are personal – and they say more about the limitations of those who make them than they do about the limitations of Darwinian mechanisms."
Well lets try to turn that around:
"Anyone can state at any time that they can easily imagine how evolutionary mechanisms might have produced a certain species, organ, structure. Such statements, obviously, are personal – and they say more about the vivid imagination of those who make them than they do about the actual probable capabilities of Darwinian mechanisms."
CreateThis - 06 Mar 2006 14:49 GMT > Quote: > [quoted text clipped - 11 lines] > more about the vivid imagination of those who make them than they do > about the actual probable capabilities of Darwinian mechanisms." Imagining ways that evolution could work disproves the claim that it couldn't - and shows the pessimists' imagination to be disfunctional.
But scientists haven't only imagined ways that evolution could work; they've also shown that it *does* work. The pessimists have only shown that they don't *want* it to work.
CT
TomS - 06 Mar 2006 15:13 GMT "On Mon, 06 Mar 2006 14:49:08 GMT, in article <EZXOf.66443$PL5.43767@newssvr11.news.prodigy.com>, CreateThis stated..."
>> Quote: >> [quoted text clipped - 18 lines] >they've also shown that it *does* work. The pessimists have only shown >that they don't *want* it to work. And the "pessimists", they haven't *even* *imagined* the ways that design could work.
 Signature ---Tom S. <http://talkreason.org/articles/chickegg.cfm> "It is not too much to say that every indication of Design in the Kosmos is so much evidence against the Omnipotence of the Designer. ... The evidences ... of Natural Theology distinctly imply that the author of the Kosmos worked under limitations..." John Stuart Mill, "Theism", Part II
Thurisaz the Einherjer - 04 Mar 2006 06:29 GMT > One of the most common ways that > Irreducible Complexity is used is in the flagellum on some kinds of > single-celled bacteria. One of the most common lies used by the IDiots is the claim that the bacterial flagellum is irreducibly complex.
 Signature Romans 2:24 revised: "For the name of God is blasphemed among the Gentiles through you cretinists, as it is written on aig."
Why I am not a christian: http://www.carcosa.de/nojebus/nojebus
Ray - 04 Mar 2006 06:51 GMT quote:
"Irreducibly complex structures, we are told, could not have been produced by evolution, or, for that matter, by any natural process. They do exist, however, and therefore they must have been produced by something. That something could only be an outside intelligent agency operating beyond the laws of nature – an intelligent designer."
An intelligent designer does not have to operate beyond the laws of nature, he could simply utilize them in his work (which is actually what he does).
Ray - 04 Mar 2006 07:24 GMT quote:
"Unfortunately for this line of argument, the claim that one irreducibly-complex system might contain another is self-contradictory. To understand this, we need to remember that the entire point of the design argument, as exemplified by the flagellum, is that only the entire biochemical machine, with all of its parts, is functional. For the intelligent design argument to stand, this must be the case, since it provides the basis for their claim that only the complete flagellum can be favored by natural selection, not any its component parts.
However, if the flagellum contains within it a smaller functional set of components like the TTSS, then the flagellum itself cannot be irreducibly complex – by definition. Since we now know that this is indeed the case, it is obviously true that the flagellum is not irreducibly complex."
comment:
Obviously, an intelligent designer can place as many IC systems nested within each other, as he likes (we do ourselves, in our designs). Their development can be programmed into the original DNA / gene blueprints, just like anything else in the organism is.
Frank J - 04 Mar 2006 20:59 GMT > Irreducible Complexity is a term invented and used by modern > Biochemists to explain the complexity of the cell and how all the parts > work together. Except that there's no agreement on the definition. Some scientists say that certain biochemical systems are irreducibly complex, but can be prodiced via evolution. Others say that those systems aren't really irreducibly complex.
While the phrase was used before in biology, pseudoscientists have hijacked it to pretend that IC invalidates evolution and is "evidence for design." There's no reason that it would have to be both, of course, despite the pseudoscientists' assertion to that effect. And in fact it does neither. And it certainly provides no support for a potential alternative theory.
But IC-speak fools the public, and that's all the pseudoscientists really want. I don't know if it was intentional or just a bonus, but they managed to get their critics to sound confused by not agreeing on a definition and sticking to it. Nevertheless, it should be no surprise that, after a decade of IC-speak, the pseudoscientists have not published one iota of original research that would back up their grandiose claims.
(snip)
Richard Smol - 04 Mar 2006 21:23 GMT > Irreducible Complexity is a term invented and used by modern > Biochemists *Bzzzzt* ... wrong. It is invented and used by creationists only. Thanks for playing.
RS
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