acetal hydrolysis

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koteshwar - 15 Mar 2005 09:44 GMT

Hello,
I would like to prepare alpha chloroacetaldehyde from alpha
chloroacetaldehyde dimethyl acetal. i have tried all possible routes
in lit using PTSA, Sulphuric acid, hydrochloric acid etc.But i am not
able to get the complete chloroacetaldehyde.
please can you suggest me way making of chloroacetaldehyde.

koteshwar

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josef muller - 16 Mar 2005 10:11 GMT

this i found in j. org. chem. 1988, 53, 15, 3457-3465.

2-Chloroacetaldehyde (72). A mixture of acetal 71 (4 mL,
35 mmol), water (3.5 mL), and 1 N HC1 (0.5 mL) was heated to
90 "C in an oil bath. The two-phase system became clear and
homogenous after 1 h. The temperature of the oil bath was raised
and a fraction distilling at 80-95 "C was removed. The residue
was neutralized by the addition of 1 N NaOH. This material was
used for enzymatic assay without further purification.

> Hello,
> I would like to prepare alpha chloroacetaldehyde from alpha
[quoted text clipped - 4 lines]
>
> koteshwar

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Natural Science Forum / Chemistry / Organic Synthesis / March 2005

acetal hydrolysis