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Natural Science Forum / Chemistry / Organic Synthesis / August 2005Amino Group to Hydroxyl Conversion?
How might I turn this: HOOC-CH2-CH2-NH2 into this: HOOC-CH2-CH2-OH in the least complex and expensive manner possible? Thank you for your time. > How might I turn this: > [quoted text clipped - 6 lines] > in the least complex and expensive manner possible? > Thank you for your time. Nitrous acid  Signature-- Ron Jones Drog napisal(a): > How might I turn this: > [quoted text clipped - 6 lines] > in the least complex and expensive manner possible? > Thank you for your time. You have to use Sandmeyer reaction. It is usualy used with aromatic amines but also with alifatic. R-NH2 + NaNO2 + H2SO4(or HCl) --> [(R-N2+)2SO4-2] + H3O+ --> R-OH There is need to control tempreture, duration about 30 hours. Tetrahedrom 28, p4131 (1972) JOC 53, p3621 (1988) JACS 110, p940 (1988) Try with some of these articles. |
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