Natural Science Forum / Chemistry / Organic Synthesis / August 2005

I believe that you can find the prep in Houben Weyl monography in
volume about derivatives of phosphoric acid.

Also, glycerol is commercialy available as 1,2-isopropylidene acetal.
Phosphorylation with POCl3/NEt3 in THF at -20C will give you the
dichlorophosphate, which can be hydrolyzed during workup. Then you
cleave the acetal. The product isolation may be tricky so you want to
use a published procedure. And you probably need opticaly pure starting
acetal, which can be obetained either from manitol diacetonide or
ascorbic acid acetonide (depending on which enantiomer you need).

Why making it when you can buy it?