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Natural Science Forum / Chemistry / Organic Synthesis / March 2006



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H2N-CH2-SH

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mark.michaels@hotmail.com - 08 Mar 2006 08:46 GMT
Hello,

I'm searching for information on and sources of H2N-CH2-SH.
2-mercaptoethylamine H2N-CH2-CH2-SH is available but one
methylene too long. I want to react H2N-CH2-SH with cysteine
in a protein to yield a lysine like side-chain except for the S-S.
The idea is to try and "rescue" the inactive lys>cys mutation.
Any tips, suggestion ... greatly appreciated

mark.michael@hotmail.com
Oscar Lanzi III - 15 Mar 2006 10:33 GMT
When I look up C5H5NS in Google, I find nothing that indicates the
existence of this compound.  I find only a couple items and they seem to
involve calculations for hypothetical molecules and fragments, not
anything done with an actual compound having this formula.  By contrast
sources and uses for "cysteamine" are easy to find when I put in C2H7NS.

I'll go out on a limb and suggest that with two protic functions on the
same carbon you don't have a stable compound.  That's why it's hard to
find both in the real world and in the Google world.

--OL
hanson - 16 Mar 2006 13:32 GMT
> When I look up C5H5NS in Google, I find nothing that
> indicates the existence of this compound.

[hanson]
C5H5NS could be o, m or para Thio-Pyridine,
= 2, 3, or 4-Mercapto Pyridine: Py-SH
CAS No: 2637-34-5
554 google hits for == Thio-Pyridine  ==
Bad stinky stuff
hanson

---------
> When I look up C5H5NS in Google, I find nothing that indicates the
> existence of this compound.  I find only a couple items and they seem to
[quoted text clipped - 7 lines]
>
> --OL
Oscar Lanzi III - 20 Mar 2006 13:23 GMT
That was a typo, in the posting not the Google search.  I meant to say
(and I looked up in Google) CH5NS.

--OL





Namast? - 29 Mar 2006 09:03 GMT
Did you know something about the compound? The procedure that you want
to carry over is a known one? and you want the reagent? or do you not
know anithing about that, and you are trying to make aproachs to the
goal?
This is because I don't think that this compound will be an easy one.
Of course that have great chances to be volatil (and with a great
odor!!!). And the worst, this compound is an amino thio acetal of the
formaldehyde (two heteroatoms attached to the same carbon atom) and in
theory it has to be unstable.
But...in chemistry the theory goes a step back the practice.
 
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