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Natural Science Forum / Chemistry / Organic Synthesis / December 2003HOW to synthese "4-chloro-3,5-dimethylphenol"??? thanks!!!
well, how to get "4-chloro-3,5-dimethylphenol" from benzene or 1,3-dimethylbenzene? thanks to everyone who can help me on it. email to ironmouth@263.net with title: symthesis approach! thank u!  SignaturePaul J. Franklin(moderator - sci.chem.organic.synthesis) http://organicworldwide.net/sci.chem.organic.synthesis Georgia State University <chepjf@panther.gsu.edu> Atlanta, GA > well, how to get "4-chloro-3,5-dimethylphenol" from benzene or > 1,3-dimethylbenzene? thanks to everyone who can help me on it. > > email to ironmouth@263.net > with title: symthesis approach! > thank u! You have some really big steric troubles there. I'd start with 2,6-dimethylaniline, introduce the para-OH, then diazotize and Sandmeyer. Looks ugly. SignatureUncle Al http://www.mazepath.com/uncleal/ (Toxic URL! Unsafe for children and most mammals) "Quis custodiet ipsos custodes?" The Net! -- Paul J. Franklin(moderator - sci.chem.organic.synthesis) http://organicworldwide.net/sci.chem.organic.synthesis Georgia State University <chepjf@panther.gsu.edu> Atlanta, GA para NH2-C6H4-NO2 + 2CH3-Cl + AlCl3 --> NH2-C6H2(-CH3)2(-NO2) NH2-C6H2(-CH3)2(-NO2) + HNO2 + CuCl ---> Cl-C6H2(-CH3)2(-NO2) + H2O + N2 + Cu(2+) Cl-C6H2(-CH3)2(-NO2) + Sn + HCl ---> Cl-C6H2(-CH3)2(-NH2) Cl-C6H2(-CH3)2(-NH2) + HNO2 + H3PO3 (or EthOH) --reflux--> Cl-C6H2(-CH3)2(-OH) Ph Z > well, how to get "4-chloro-3,5-dimethylphenol" from benzene or > 1,3-dimethylbenzene? thanks to everyone who can help me on it. > > email to ironmouth@263.net > with title: symthesis approach! > thank u! SignaturePaul J. Franklin(moderator - sci.chem.organic.synthesis) http://organicworldwide.net/sci.chem.organic.synthesis Georgia State University <chepjf@panther.gsu.edu> Atlanta, GA |
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