Natural Science Forum / Chemistry / Organic Synthesis / February 2004

Hello all

Anyone got any good references for the bromination of methoxy anisoles: I
want to brominate the acetophenone but I suspect the usual conditions will
remove the methyl group.  I found a reference to the reaction below but the
yield was below 50 % T and it had column chromatography as a work up.

Reaction in smiles:- COC1=CC=CC=C1C(C)=O plus bromine giving
COC1=CC=CC=C1C(CBr)=O

Any leads appreciated and I'm open to a discussion as to methylating the
phenol post bromination.

Thanks ... Darren.

ps for those unfamilliar with smiles:- http://www.daylight.com/daycgi/depict