Natural Science Forum / Chemistry / Organic Synthesis / February 2004

What is the reaction between 3-nitroaniline and methylene chloride (CH2CL2) ?

I am looking to alkylate 4.4'-diaminobenzophenone, first with an ethyl
group (symmetrical) but later with other alkyl groups (your stand sort
of medi chem type thing)  I thought puting base or NEt3 with ethyliodide
would do the trick, but alas the TLC showed nothin'   I am ...

I've synthesized (3R,5S)-1-(t-butyloxycarbonyl)-3-fluoro-5-(trityloxymethyl)-2-pyrrolidinone
as a precursor to L-erythro-4-fluoroglutamine, but am having trouble
purifying it.  My reference says use hexanes/ethyl acetate (4:1) but
for some reason the entire sample binds strongly to ...

I need a little help from organic chemists.
I have an alcoholic mix: ethanol (10%) + isopropanol (80%) + H20
(10%).
I add some NaOH and H2O2.

          Can anyone tell me the procedure for drying HMPA?

I'm trying to protect the amine group in L-glutamine by using a protecting
group.  I've tried the CBz group, but the removal with Pd/H2 is inconvenient
and often doesn't work consistently.  I'd like to try another group, and
have thought about the p-methoxybenzyl group.  The goal is ...

Anyone got any good references for the bromination of methoxy anisoles: I
want to brominate the acetophenone but I suspect the usual conditions will
remove the methyl group.  I found a reference to the reaction below but the
yield was below 50 % T and it had column chromatography as ...

Aluminium butoxide is given in references for the Oppenauer oxidation - has
anyone had any experience of using other bases?
Darren.

Can chloropyridines be converted to Grignard reagents? I am told that
cannot be done. I wonder if that's true.

I'm looking for a mechanism for butylated hydroxytoluene. It looks
like it would be a simple ortho/para director type problem, but I
haven't worked w/ organic materials in a long time. Also, is there a
place that I could find out the time it would take to synthesis BHT in

Doing solanesylacetone by condensing ethyl acetoacetate with solanesyl
bromide and subsequent decarboxylation at 80°C in the presence of aqueous
NaOH cause the formation of some unexpected stereoisomers. How can I do to
avoid this formation and to abtain steromerically pure ...

I have to produce 4-Bromoacetanilide with 4-Bromoaniline and acetic
ahydrid.
The first manipulation of the experience is to take 2,5 g of
4-Bromoaniline, to put this in a erlenmeyer and to add 50 ml of water

Hi NG!
Any idea on the exact synthesis of  Phosphorus trichloride?
Thanks